Review



alk1 2 inhibitor  (Tocris)


Bioz Verified Symbol Tocris is a verified supplier
Bioz Manufacturer Symbol Tocris manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 91
      Buy from Supplier

    Structured Review

    Tocris alk1 2 inhibitor
    Library of signaling pathway modulators.
    Alk1 2 Inhibitor, supplied by Tocris, used in various techniques. Bioz Stars score: 91/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/alk1 2 inhibitor/product/Tocris
    Average 91 stars, based on 10 article reviews
    alk1 2 inhibitor - by Bioz Stars, 2026-06
    91/100 stars

    Images

    1) Product Images from "Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like Structures"

    Article Title: Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like Structures

    Journal: Advanced Science

    doi: 10.1002/advs.202304987

    Library of signaling pathway modulators.
    Figure Legend Snippet: Library of signaling pathway modulators.

    Techniques Used: Concentration Assay



    Similar Products

    ml 347  (Bio-Techne corporation)
    93
    Bio-Techne corporation ml 347
    Ml 347, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ml 347/product/Bio-Techne corporation
    Average 93 stars, based on 1 article reviews
    ml 347 - by Bioz Stars, 2026-06
    93/100 stars
    		  Buy from Supplier
    alk1 2 6 inhibitor k02288  (Selleck Chemicals)
    94
    Selleck Chemicals alk1 2 6 inhibitor k02288
    Alk1 2 6 Inhibitor K02288, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/alk1 2 6 inhibitor k02288/product/Selleck Chemicals
    Average 94 stars, based on 1 article reviews
    alk1 2 6 inhibitor k02288 - by Bioz Stars, 2026-06
    94/100 stars
    		  Buy from Supplier
    alk1 2 inhibitor  (Tocris)
    91
    Tocris alk1 2 inhibitor
    Library of signaling pathway modulators.
    Alk1 2 Inhibitor, supplied by Tocris, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/alk1 2 inhibitor/product/Tocris
    Average 91 stars, based on 1 article reviews
    alk1 2 inhibitor - by Bioz Stars, 2026-06
    91/100 stars
    		  Buy from Supplier
    ml347 alk1 2 inhibitor tocris  (Selleck Chemicals)
    96
    Selleck Chemicals ml347 alk1 2 inhibitor tocris
    Library of signaling pathway modulators.
    Ml347 Alk1 2 Inhibitor Tocris, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ml347 alk1 2 inhibitor tocris/product/Selleck Chemicals
    Average 96 stars, based on 1 article reviews
    ml347 alk1 2 inhibitor tocris - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier
    ml347 alk1 2 inhibitor tocris  (Tocris)
    93
    Tocris ml347 alk1 2 inhibitor tocris
    Library of signaling pathway modulators.
    Ml347 Alk1 2 Inhibitor Tocris, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ml347 alk1 2 inhibitor tocris/product/Tocris
    Average 93 stars, based on 1 article reviews
    ml347 alk1 2 inhibitor tocris - by Bioz Stars, 2026-06
    93/100 stars
    		  Buy from Supplier
    alk1 2 inhibitor  (Selleck Chemicals)
    94
    Selleck Chemicals alk1 2 inhibitor
    Library of signaling pathway modulators.
    Alk1 2 Inhibitor, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/alk1 2 inhibitor/product/Selleck Chemicals
    Average 94 stars, based on 1 article reviews
    alk1 2 inhibitor - by Bioz Stars, 2026-06
    94/100 stars
    		  Buy from Supplier
    alk1 2 inhibitor ml347  (Tocris)
    93
    Tocris alk1 2 inhibitor ml347
    ALK3 and ALK6 are required for GDF2-induced SMAD1/5 phosphorylation. (A-B) Western blotting for pSMAD1/5 activation in PA1 and MCF10A cells in the presence and absence of dorsomorphin 1 μM (+) or 3 μM (++), SB431542 3 μM (+) or 5 μM (++), or <t>ML347</t> 500 nM (+) or 1 mM (++) as indicated with and without GDF2 (10 ng/ml) as indicated (quantification of pSMAD1/5 levels presented in Supplementary Figure S2 C ). (C) Immunoblotting of pSMAD1/5 in PA1 cells in the presence of shRNAs to ALK2, ALK3, ALK6, and BMPRII without and with GDF2 treatment (10 ng/ml) for 30 minutes. (D) QRT-PCR analyses of (C) to confirm reduced expression of ALK2, ALK3, ALK6, and BMPRII expression as indicated. (E) Kinase inactive ALK3 and ALK6 inhibit SMAD1/5 phosphorylation. Western blotting as indicated in MCF10A and PA1 cells in the presence of either mock transfected or HA-tagged kinase inactive ALK3 (ALK3 K-R) or ALK6 (ALK6 K-R) and treated with GDF2 for the time points indicated. Actin was the loading control. (F) Dorsomorphin inhibits SMAD1/5 transcriptional activation. BRE-luciferase reporter activity in indicated cells in the absence (GDF2 alone) or presence of 1 μM dorsomorphin (GDF2+DM). Fold induction of luciferase activity compared with DMSO-treated control cells is presented.
    Alk1 2 Inhibitor Ml347, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/alk1 2 inhibitor ml347/product/Tocris
    Average 93 stars, based on 1 article reviews
    alk1 2 inhibitor ml347 - by Bioz Stars, 2026-06
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Library of signaling pathway modulators.

    Journal: Advanced Science

    Article Title: Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like Structures

    doi: 10.1002/advs.202304987

    Figure Lengend Snippet: Library of signaling pathway modulators.

    Article Snippet: ML347 , ALK1/2 inhibitor , Tocris 4945 , 1.5 μ m.

    Techniques: Concentration Assay

    ALK3 and ALK6 are required for GDF2-induced SMAD1/5 phosphorylation. (A-B) Western blotting for pSMAD1/5 activation in PA1 and MCF10A cells in the presence and absence of dorsomorphin 1 μM (+) or 3 μM (++), SB431542 3 μM (+) or 5 μM (++), or ML347 500 nM (+) or 1 mM (++) as indicated with and without GDF2 (10 ng/ml) as indicated (quantification of pSMAD1/5 levels presented in Supplementary Figure S2 C ). (C) Immunoblotting of pSMAD1/5 in PA1 cells in the presence of shRNAs to ALK2, ALK3, ALK6, and BMPRII without and with GDF2 treatment (10 ng/ml) for 30 minutes. (D) QRT-PCR analyses of (C) to confirm reduced expression of ALK2, ALK3, ALK6, and BMPRII expression as indicated. (E) Kinase inactive ALK3 and ALK6 inhibit SMAD1/5 phosphorylation. Western blotting as indicated in MCF10A and PA1 cells in the presence of either mock transfected or HA-tagged kinase inactive ALK3 (ALK3 K-R) or ALK6 (ALK6 K-R) and treated with GDF2 for the time points indicated. Actin was the loading control. (F) Dorsomorphin inhibits SMAD1/5 transcriptional activation. BRE-luciferase reporter activity in indicated cells in the absence (GDF2 alone) or presence of 1 μM dorsomorphin (GDF2+DM). Fold induction of luciferase activity compared with DMSO-treated control cells is presented.

    Journal: Neoplasia (New York, N.Y.)

    Article Title: Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia 1

    doi: 10.1016/j.neo.2015.11.003

    Figure Lengend Snippet: ALK3 and ALK6 are required for GDF2-induced SMAD1/5 phosphorylation. (A-B) Western blotting for pSMAD1/5 activation in PA1 and MCF10A cells in the presence and absence of dorsomorphin 1 μM (+) or 3 μM (++), SB431542 3 μM (+) or 5 μM (++), or ML347 500 nM (+) or 1 mM (++) as indicated with and without GDF2 (10 ng/ml) as indicated (quantification of pSMAD1/5 levels presented in Supplementary Figure S2 C ). (C) Immunoblotting of pSMAD1/5 in PA1 cells in the presence of shRNAs to ALK2, ALK3, ALK6, and BMPRII without and with GDF2 treatment (10 ng/ml) for 30 minutes. (D) QRT-PCR analyses of (C) to confirm reduced expression of ALK2, ALK3, ALK6, and BMPRII expression as indicated. (E) Kinase inactive ALK3 and ALK6 inhibit SMAD1/5 phosphorylation. Western blotting as indicated in MCF10A and PA1 cells in the presence of either mock transfected or HA-tagged kinase inactive ALK3 (ALK3 K-R) or ALK6 (ALK6 K-R) and treated with GDF2 for the time points indicated. Actin was the loading control. (F) Dorsomorphin inhibits SMAD1/5 transcriptional activation. BRE-luciferase reporter activity in indicated cells in the absence (GDF2 alone) or presence of 1 μM dorsomorphin (GDF2+DM). Fold induction of luciferase activity compared with DMSO-treated control cells is presented.

    Article Snippet: ALK1/2 inhibitor ML347 (#4945) was from Tocris Bioscience.

    Techniques: Phospho-proteomics, Western Blot, Activation Assay, Quantitative RT-PCR, Expressing, Transfection, Control, Luciferase, Activity Assay